Latent Membrane Protein 1 (LMP1) and LMP2A Collaborate To Promote Epstein-Barr Virus-Induced B Cell Lymphomas in a Cord Blood-Humanized Mouse Model but Are Not Essential

Epstein-Barr virus (EBV) infection is associated with B cell lymphomas in humans. The ability of EBV to convert human B cells into long-lived lymphoblastoid cell lines (LCLs) in vitro requires the collaborative effects of EBNA2 (which hijacks Notch signaling), latent membrane protein 1 (LMP1) (which...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Ma, Shi-Dong, Tsai, Ming-Han, Romero-Masters, James C., Ranheim, Erik A., Huebner, Shane M., Bristol, Jillian A., Delecluse, Henri-Jacques, Kenney, Shannon C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Transformation and Oncogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355617/
https://ncbi.nlm.nih.gov/pubmed/28077657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01928-16
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