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A Temperature-Sensitive Lesion in the N-Terminal Domain of the Rotavirus Polymerase Affects Its Intracellular Localization and Enzymatic Activity

Temperature-sensitive (ts) mutants of simian rotavirus (RV) strain SA11 have been previously created to investigate the functions of viral proteins during replication. One mutant, SA11-tsC, has a mutation that maps to the gene encoding the VP1 polymerase and shows diminished growth and RNA synthesis...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: McKell, Allison O., LaConte, Leslie E. W., McDonald, Sarah M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355613/
https://ncbi.nlm.nih.gov/pubmed/28100623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00062-17
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