Rotation Mechanism of Molecular Motor V(1)-ATPase Studied by Multiscale Molecular Dynamics Simulation

Enterococcus hirae V(1)-ATPase is a molecular motor composed of the A(3)B(3) hexamer ring and the central stalk. In association with ATP hydrolysis, three catalytic AB pairs in the A(3)B(3) ring undergo conformational changes, which lead to a 120° rotation of the central stalk. To understand how the...

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Bibliographic Details
Published in:Biophys J
Main Authors: Isaka, Yuta, Ekimoto, Toru, Kokabu, Yuichi, Yamato, Ichiro, Murata, Takeshi, Ikeguchi, Mitsunori
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2017
Subjects:
Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355535/
https://ncbi.nlm.nih.gov/pubmed/28297650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.01.029
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