Autocrine VEGF signaling promotes cell proliferation through a PLC-dependent pathway and modulates Apatinib treatment efficacy in gastric cancer

BACKGROUND: Tumor cells produce vascular endothelial growth factor (VEGF) which interact with the membrane or cytoplasmic VEGF receptors (VEGFRs) to promote cell growth in an angiogenesis-independent fashion. Apatinib, a highly selective VEGFR2 inhibitor, is the only effective drug for patients with...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lin, Yi, Zhai, Ertao, Liao, Bing, Xu, Lixia, Zhang, Xinhua, Peng, Sui, He, Yulong, Cai, Shirong, Zeng, Zhirong, Chen, Minhu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355320/
https://ncbi.nlm.nih.gov/pubmed/28061477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14467
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