The pentapeptide Gly-Thr-Gly-Lys-Thr confers sensitivity to anti-cancer drugs by inhibition of CAGE binding to GSK3β and decreasing the expression of cyclinD1

We previously reported the role of cancer/testis antigen CAGE in the response to anti-cancer drugs. CAGE increased the expression of cyclinD1, and pGSK3β(Ser9), an inactive GSK3β, while decreasing the expression of phospho-cyclinD1Thr(286). CAGE showed binding to GSK3β and the domain of CAGE (amino...

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Publicat a:Oncotarget
Autors principals: Kim, Youngmi, Kim, Hyuna, Park, Deokbum, Lee, Hansoo, Lee, Yun Sil, Choe, Jongseon, Kim, Young Myeong, Jeon, Doyong, Jeoung, Dooil
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355126/
https://ncbi.nlm.nih.gov/pubmed/28099142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14621
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