Cancer/Testis Antigen CAGE Exerts Negative Regulation on p53 Expression through HDAC2 and Confers Resistance to Anti-cancer Drugs

The role of the cancer/testis antigen CAGE in drug resistance was investigated. The drug-resistant human melanoma Malme3M (Malme3M(R)) and the human hepatic cancer cell line SNU387 (SNU387(R)) showed in vivo drug resistance and CAGE induction. Induction of CAGE resulted from decreased expression and...

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Detalhes bibliográficos
Main Authors: Kim, Youngmi, Park, Hyunmi, Park, Deokbum, Lee, Yun-Sil, Choe, Jongseon, Hahn, Jang-Hee, Lee, Hansoo, Kim, Young-Myeong, Jeoung, Dooil
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923988/
https://ncbi.nlm.nih.gov/pubmed/20534591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.095950
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