Bone pain induced by multiple myeloma is reduced by targeting V-ATPase and ASIC3

Multiple myeloma (MM) patients experience severe bone pain (MMBP) that is undertreated and poorly understood. In this study, we studied MMBP in an intratibial mouse xenograft model which employs JJN3 human MM cells. In this model, mice develop MMBP associated in bone with increased sprouting of calc...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Hiasa, Masahiro, Okui, Tatsuo, Allette, Yohance M, Ripsch, Matthew S, Sun-Wada, Ge-Hong, Wakabayashi, Hiroki, Roodman, G David, White, Fletcher A., Yoneda, Toshiyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355000/
https://ncbi.nlm.nih.gov/pubmed/28254863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-3545
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