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Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation

Lung cancer is a deadly disease with increasing cases diagnosed worldwide and still a very poor prognosis. While mutations in the retinoblastoma (RB1) tumor suppressor have been reported in lung cancer, mainly in small cell lung carcinoma, the tumor suppressive role of its relatives p107 and p130 is...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Lázaro, Sara, Pérez-Crespo, Miriam, Enguita, Ana Belén, Hernández, Pilar, Martínez-Palacio, Jesús, Oteo, Marta, Sage, Julien, Paramio, Jesús M., Santos, Mirentxu
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354839/
https://ncbi.nlm.nih.gov/pubmed/27966456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13875
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