Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity

In this report, we systematically examined the role of telomerase activity in lung and ovarian cancer stem cell (CSC) propagation. For this purpose, we indirectly gauged telomerase activity, by linking the hTERT-promoter to eGFP. Using lung (A549) and ovarian (SKOV3) cancer cells, transduced with th...

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Vydáno v:Oncotarget
Hlavní autoři: Bonuccelli, Gloria, Peiris-Pages, Maria, Ozsvari, Bela, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354777/
https://ncbi.nlm.nih.gov/pubmed/28039467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14196
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