Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity

In this report, we systematically examined the role of telomerase activity in lung and ovarian cancer stem cell (CSC) propagation. For this purpose, we indirectly gauged telomerase activity, by linking the hTERT-promoter to eGFP. Using lung (A549) and ovarian (SKOV3) cancer cells, transduced with th...

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Publicat a:Oncotarget
Autors principals: Bonuccelli, Gloria, Peiris-Pages, Maria, Ozsvari, Bela, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354777/
https://ncbi.nlm.nih.gov/pubmed/28039467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14196
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