EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions

Multiple Myeloma (MM) is a plasma cell tumor localized to the bone marrow (BM). Despite the fact that current treatment strategies have improved patients' median survival time, MM remains incurable. Epigenetic aberrations are emerging as important players in tumorigenesis making them attractive...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Alzrigat, Mohammad, Párraga, Alba Atienza, Agarwal, Prasoon, Zureigat, Hadil, Österborg, Anders, Nahi, Hareth, Ma, Anqi, Jin, Jian, Nilsson, Kenneth, Öberg, Fredrik, Kalushkova, Antonia, Jernberg-Wiklund, Helena
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2016
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354653/
https://ncbi.nlm.nih.gov/pubmed/28052011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14378
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