BRCA1-IRIS overexpression promotes and maintains the tumor initiating phenotype: implications for triple negative breast cancer early lesions

Tumor-initiating cells (TICs) are cancer cells endowed with self-renewal, multi-lineage differentiation, increased chemo-resistance, and in breast cancers the CD44(+)/CD24(-)/ALDH1(+) phenotype. Triple negative breast cancers show lack of BRCA1 expression in addition to enhanced basal, epithelial-to...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Sinha, Abhilasha, Paul, Bibbin T., Sullivan, Lisa M., Sims, Hillary, Bastawisy, Ahmed El, Yousef, Hend F., Zekri, Abdel-Rahman N., Bahnassy, Abeer A., ElShamy, Wael M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354646/
https://ncbi.nlm.nih.gov/pubmed/28052035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14357
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