TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation

The intensity and duration of TGF-β signaling determine the cellular biological response. How this is negatively regulated is not well understood. Here, we identified a novel negative regulator of TGF-β signaling, transmembrane p24-trafficking protein 10 (TMED10). TMED10 disrupts the complex formati...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Nakano, Naoko, Tsuchiya, Yuki, Kako, Kenro, Umezaki, Kenryu, Sano, Keigo, Ikeno, Souichi, Otsuka, Eri, Shigeta, Masashi, Nakagawa, Ai, Sakata, Nobuo, Itoh, Fumiko, Nakano, Yota, Iemura, Shun-ichiro, van Dinther, Maarten, Natsume, Tohru, ten Dijke, Peter, Itoh, Susumu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354491/
https://ncbi.nlm.nih.gov/pubmed/28115518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.769109
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