IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients

Despite the success of immune checkpoint blockade in melanoma, the majority of patients do not respond. We hypothesized that the T and NK cell subset frequencies and expression levels of their receptors may predict responses and clinical outcome of anti-CTLA-4 treatment. We thus characterized the NK...

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Publicat a:Oncoimmunology
Autors principals: Tallerico, Rossana, Cristiani, Costanza M., Staaf, Elina, Garofalo, Cinzia, Sottile, Rosa, Capone, Mariaelena, Pico de Coaña, Yago, Madonna, Gabriele, Palella, Eleonora, Wolodarski, Maria, Carannante, Valentina, Mallardo, Domenico, Simeone, Ester, Grimaldi, Antonio M., Johansson, Sofia, Frumento, Paolo, Gulletta, Elio, Anichini, Andrea, Colucci, Francesco, Ciliberto, Gennaro, Kiessling, Rolf, Kärre, Klas, Ascierto, Paolo A., Carbone, Ennio
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353942/
https://ncbi.nlm.nih.gov/pubmed/28344869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1261242
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