IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients

Despite the success of immune checkpoint blockade in melanoma, the majority of patients do not respond. We hypothesized that the T and NK cell subset frequencies and expression levels of their receptors may predict responses and clinical outcome of anti-CTLA-4 treatment. We thus characterized the NK...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Tallerico, Rossana, Cristiani, Costanza M., Staaf, Elina, Garofalo, Cinzia, Sottile, Rosa, Capone, Mariaelena, Pico de Coaña, Yago, Madonna, Gabriele, Palella, Eleonora, Wolodarski, Maria, Carannante, Valentina, Mallardo, Domenico, Simeone, Ester, Grimaldi, Antonio M., Johansson, Sofia, Frumento, Paolo, Gulletta, Elio, Anichini, Andrea, Colucci, Francesco, Ciliberto, Gennaro, Kiessling, Rolf, Kärre, Klas, Ascierto, Paolo A., Carbone, Ennio
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353942/
https://ncbi.nlm.nih.gov/pubmed/28344869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1261242
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