Prostaglandin E(2)-mediated adenosinergic effects on CD14(+) cells: Self-amplifying immunosuppression in cancer

CD39 and CD73 are surface-expressed ectonucleotidases that hydrolyze ATP in a highly regulated, serial manner into ADP, AMP and adenosine. The end product, adenosine, has both tumor-promoting and immunosuppressive effects. The aim of this study was to determine CD73 expression on immune cells in ple...

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Publicat a:Oncoimmunology
Autors principals: Al-Taei, Saly, Salimu, Josephine, Spary, Lisa K., Clayton, Aled, Lester, Jason F., Tabi, Zsuzsanna
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353926/
https://ncbi.nlm.nih.gov/pubmed/28344879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1268308
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