2B4-SAP signaling is required for the priming of naive CD8(+) T cells by antigen-expressing B cells and B lymphoma cells

Mutations in SH2D1A gene that encodes SAP (SLAM-associated protein) result in X-linked lymphoproliferative disease (XLP), a rare primary immunodeficiency disease defined by exquisite sensitivity to the B-lymphotropic Epstein–Barr virus (EBV) and B cell lymphomas. However, the precise mechanism of ho...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Huang, Yu-Hsuan, Tsai, Kevin, Tan, Sara Y., Kang, Sohyeong, Ford, Mandy L., Harder, Kenneth W., Priatel, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353922/
https://ncbi.nlm.nih.gov/pubmed/28344876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1267094
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