Reduced naïve CD8(+) T‐cell priming efficacy in elderly adults

Aging is associated with impaired vaccine efficacy and increased susceptibility to infectious and malignant diseases. CD8(+) T‐cells are key players in the immune response against pathogens and tumors. In aged mice, the dwindling naïve CD8(+) T‐cell compartment is thought to compromise the induction...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Briceño, Olivia, Lissina, Anna, Wanke, Kerstin, Afonso, Georgia, von Braun, Amrei, Ragon, Kristanto, Miquel, Tiphaine, Gostick, Emma, Papagno, Laura, Stiasny, Karin, Price, David A., Mallone, Roberto, Sauce, Delphine, Karrer, Urs, Appay, Victor
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717282/
https://ncbi.nlm.nih.gov/pubmed/26472076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12384
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