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Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation

The human cytomegalovirus 72-kDa immediate-early (IE)1 and 86-kDa IE2 proteins are expressed at the start of infection, and they are believed to exert much of their function through promiscuous transcriptional activation of viral and cellular gene expression. Here, we show that the impaired growth o...

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Autors principals: Nevels, Michael, Paulus, Christina, Shenk, Thomas
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC535392/
https://ncbi.nlm.nih.gov/pubmed/15572445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407933101
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