Generation of non-viral, transgene-free hepatocyte like cells with piggyBac transposon

Somatic cells can be reprogrammed to induced hepatocyte-like cells (iHeps) by overexpressing certain defined factors in direct reprogramming techniques. Of the various methods to deliver genes into cells, typically used genome-integrating viral vectors are associated with integration-related adverse...

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Publicado en:Sci Rep
Main Authors: Katayama, Hokahiro, Yasuchika, Kentaro, Miyauchi, Yuya, Kojima, Hidenobu, Yamaoka, Ryoya, Kawai, Takayuki, Yukie Yoshitoshi, Elena, Ogiso, Satoshi, Kita, Sadahiko, Yasuda, Katsutaro, Sasaki, Naoya, Fukumitsu, Ken, Komori, Junji, Ishii, Takamichi, Uemoto, Shinji
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353749/
https://ncbi.nlm.nih.gov/pubmed/28295042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44498
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