A novel three-dimensional culture system maintaining the physiological extracellular matrix of fibrotic model livers accelerates progression of hepatocellular carcinoma cells

Liver fibrosis is characterized by the progressive accumulation of extracellular matrix (ECM) and is a strong predictor of hepatocellular carcinoma (HCC) development and progression. However, the effect of ECM in fibrotic livers on HCC cells is poorly understood. The aims of this study were to creat...

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Udgivet i:Sci Rep
Main Authors: Miyauchi, Yuya, Yasuchika, Kentaro, Fukumitsu, Ken, Ishii, Takamichi, Ogiso, Satoshi, Minami, Takahito, Kojima, Hidenobu, Yamaoka, Ryoya, Katayama, Hokahiro, Kawai, Takayuki, Yoshitoshi-Uebayashi, Elena Yukie, Kita, Sadahiko, Yasuda, Katsutaro, Sasaki, Naoya, Uemoto, Shinji
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575302/
https://ncbi.nlm.nih.gov/pubmed/28851916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09391-y
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