Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7

Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease. Preclinical and experimental studies show that PDE5 inhibitors (PDE5is) exert protective effects in DN improving perivascular inflammation. Using a mouse model of diabetic kidney injury we investigated the protective propriet...

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Pubblicato in:Sci Rep
Autori principali: Pofi, Riccardo, Fiore, Daniela, De Gaetano, Rita, Panio, Giuseppe, Gianfrilli, Daniele, Pozza, Carlotta, Barbagallo, Federica, Xiang, Yang Kevin, Giannakakis, Konstantinos, Morano, Susanna, Lenzi, Andrea, Naro, Fabio, Isidori, Andrea M., Venneri, Mary Anna
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353686/
https://ncbi.nlm.nih.gov/pubmed/28294194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44584
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