Chronic Inhibition of PDE5 Limits Pro-Inflammatory Monocyte-Macrophage Polarization in Streptozotocin-Induced Diabetic Mice

Diabetes mellitus is characterized by changes in endothelial cells that alter monocyte recruitment, increase classic (M1-type) tissue macrophage infiltration and lead to self-sustained inflammation. Our and other groups recently showed that chronic inhibition of phosphodiesterase-5 (PDE5i) affects c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Venneri, Mary Anna, Giannetta, Elisa, Panio, Giuseppe, De Gaetano, Rita, Gianfrilli, Daniele, Pofi, Riccardo, Masciarelli, Silvia, Fazi, Francesco, Pellegrini, Manuela, Lenzi, Andrea, Naro, Fabio, Isidori, Andrea M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427327/
https://ncbi.nlm.nih.gov/pubmed/25961566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126580
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