PD-L1 Expression by Two Complementary Diagnostic Assays and mRNA In Situ Hybridization in Small Cell Lung Cancer

INTRODUCTION: Therapeutic antibodies to immune checkpoints show promising results. Programmed death-ligand 1 (PD-L1), an immune checkpoint ligand, blocks the cancer immunity cycle by binding the PD-L1 receptor (programmed death 1). We investigated PD-L1 protein expression and messenger RNA (mRNA) le...

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Publicado no:J Thorac Oncol
Main Authors: Yu, Hui, Batenchuk, Cory, Badzio, Andrzej, Boyle, Theresa A., Czapiewski, Piotr, Chan, Daniel C., Lu, Xian, Gao, Dexiang, Ellison, Kim, Kowalewski, Ashley A., Rivard, Christopher J., Dziadziuszko, Rafal, Zhou, Caicun, Hussein, Maen, Richards, Donald, Wilks, Sharon, Monte, Marc, Edenfield, William, Goldschmidt, Jerome, Page, Ray, Ulrich, Brian, Waterhouse, David, Close, Sandra, Jassem, Jacek, Kulig, Kimary, Hirsch, Fred R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353355/
https://ncbi.nlm.nih.gov/pubmed/27639678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2016.09.002
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