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Site-specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates rather than Binding Affinity

A popular strategy to overcome the limited plasma half-life of peptide heptad repeat 2 (HR2) fusion inhibitors against HIV-1 is through conjugation with biocompatible polymers such as poly(ethylene glycol) (PEG). However, despite improved resistance to proteolysis and reduced renal elimination, cova...

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Detaylı Bibliyografya
Yayımlandı:Bioconjug Chem
Asıl Yazarlar: Danial, Maarten, Stauffer, Angela N., Wurm, Frederik R., Root, Michael J., Klok, Harm-Anton
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352488/
https://ncbi.nlm.nih.gov/pubmed/27737540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.6b00540
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