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Sub-cellular Targeting as a Determinant of the Efficacy of Photodynamic Therapy
In prior studies, we have identified the ability of low-level lysosomal photodamage to potentiate the phototoxic effect of subsequent photodamage to mitochondria. The mechanism involves calpain-mediated cleavage of the autophagy-associated protein ATG5 to form a pro-apoptotic fragment (tATG5). In th...
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| Publicado no: | Photochem Photobiol |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5352468/ https://ncbi.nlm.nih.gov/pubmed/27935055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/php.12692 |
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