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Sub-cellular Targeting as a Determinant of the Efficacy of Photodynamic Therapy

In prior studies, we have identified the ability of low-level lysosomal photodamage to potentiate the phototoxic effect of subsequent photodamage to mitochondria. The mechanism involves calpain-mediated cleavage of the autophagy-associated protein ATG5 to form a pro-apoptotic fragment (tATG5). In th...

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Bibliografiske detaljer
Udgivet i:Photochem Photobiol
Hovedforfatter: Kessel, David
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352468/
https://ncbi.nlm.nih.gov/pubmed/27935055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/php.12692
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