P4HB promotes HCC tumorigenesis through downregulation of GRP78 and subsequent upregulation of epithelial-to-mesenchymal transition

P4HB and GRP78 are molecular chaperones involved in cellular response to ER stress. They have been linked to cancer progression; however, their roles in hepatocellular carcinoma (HCC) are largely unclear. In this study, we found that P4HB is overexpressed in human HCC tissues and cell lines. Higher...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Xia, Wei, Zhuang, Juhua, Wang, Guoyu, Ni, Jing, Wang, Jiening, Ye, Ying
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352418/
https://ncbi.nlm.nih.gov/pubmed/28052026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14337
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