5-Hydroxymethylcytosine correlates with epigenetic regulatory mutations, but may not have prognostic value in predicting survival in normal karyotype acute myeloid leukemia

Stem cells display remarkably high levels of 5-hydroxymethylcytosine (5hmC). Both TET2 and IDH1/2 mutations can impair the production of 5hmC, thus decreasing 5hmC levels. TET2 or IDH1/2 mutations are commonly observed in acute myeloid leukemia (AML). However, the implications of 5hmC on survival in...

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Pubblicato in:Oncotarget
Autori principali: Ahn, Jae-Sook, Kim, Hyeoung-Joon, Kim, Yeo-Kyeoung, Lee, Seung-Shin, Ahn, Seo-Yeon, Jung, Sung-Hoon, Yang, Deok-Hwan, Lee, Je-Jung, Park, Hee Jeong, Choi, Seung Hyun, Jung, Chul Won, Jang, Jun-Ho, Kim, Hee Je, Moon, Joon Ho, Sohn, Sang Kyun, Won, Jong-Ho, Kim, Sung-Hyun, Michael, Szardenings, Minden, Mark D., Hwan, Dennis Dong Kim
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352402/
https://ncbi.nlm.nih.gov/pubmed/28039446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14171
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