Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells

Nuclear factor-erythroid 2-related factor 2 (Nrf2) is persistently activated in many human tumors including acute myeloid leukemia (AML). Therefore, inhibition of Nrf2 activity may be a promising target in leukemia therapy. Here, we used an antioxidant response element-luciferase reporter system to...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhang, JinFeng, Su, Le, Ye, Qing, Zhang, ShangLi, Kung, HsiangFu, Jiang, Fan, Jiang, GuoSheng, Miao, JunYing, Zhao, BaoXiang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352348/
https://ncbi.nlm.nih.gov/pubmed/28032588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13825
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