An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E(-/-) mice

Oxidized low-density lipoprotein (oxLDL) inhibits mammalian target of rapamycin (mTOR) and induces autophagy and apoptosis in vascular endothelial cells (VECs) that play very critical roles for the cardiovascular homostasis. We recently defined 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)...

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Main Authors: Peng, Nan, Meng, Ning, Wang, ShengQing, Zhao, Fei, Zhao, Jing, Su, Le, Zhang, ShangLi, Zhang, Yun, Zhao, BaoXiang, Miao, JunYing
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076681/
https://ncbi.nlm.nih.gov/pubmed/24980430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05519
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