An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E(-/-) mice

Oxidized low-density lipoprotein (oxLDL) inhibits mammalian target of rapamycin (mTOR) and induces autophagy and apoptosis in vascular endothelial cells (VECs) that play very critical roles for the cardiovascular homostasis. We recently defined 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)...

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Detalhes bibliográficos
Main Authors: Peng, Nan, Meng, Ning, Wang, ShengQing, Zhao, Fei, Zhao, Jing, Su, Le, Zhang, ShangLi, Zhang, Yun, Zhao, BaoXiang, Miao, JunYing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076681/
https://ncbi.nlm.nih.gov/pubmed/24980430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05519
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