Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency

Epstein-Barr Virus (EBV) latent infection is a causative co-factor for endemic Nasopharyngeal Carcinoma (NPC). NPC-associated variants have been identified in EBV-encoded nuclear antigen EBNA1. Here, we solve the X-ray crystal structure of an NPC-derived EBNA1 DNA binding domain (DBD) and show that...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Dheekollu, Jayaraju, Malecka, Kimberly, Wiedmer, Andreas, Delecluse, Henri-Jacques, Chiang, Alan K.S., Altieri, Dario C., Messick, Troy E., Lieberman, Paul M
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352318/
https://ncbi.nlm.nih.gov/pubmed/28077791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14540
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