Acquired resistance to BRAF inhibition induces epithelial-to-mesenchymal transition in BRAF (V600E) mutant thyroid cancer by c-Met-mediated AKT activation

Previously, the authors have identified that c-Met mediates reactivation of the PI3K/AKT pathway following BRAF inhibitor treatment in BRAF (V600E) mutant anaplastic thyroid cancer, thereby contributing to the acquired drug resistance. Therefore dual inhibition of BRAF and c-Met led to sustained tre...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Byeon, Hyung Kwon, Na, Hwi Jung, Yang, Yeon Ju, Ko, Sooah, Yoon, Sun Och, Ku, Minhee, Yang, Jaemoon, Kim, Jae Wook, Ban, Myung Jin, Kim, Ji-Hoon, Kim, Da Hee, Kim, Jung Min, Choi, Eun Chang, Kim, Chang-Hoon, Yoon, Joo-Heon, Koh, Yoon Woo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352181/
https://ncbi.nlm.nih.gov/pubmed/27880942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13480
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