A magnesium-induced triplex pre-organizes the SAM-II riboswitch

Our (13)C- and (1)H-chemical exchange saturation transfer (CEST) experiments previously revealed a dynamic exchange between partially closed and open conformations of the SAM-II riboswitch in the absence of ligand. Here, all-atom structure-based molecular simulations, with the electrostatic effects...

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Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Roy, Susmita, Lammert, Heiko, Hayes, Ryan L., Chen, Bin, LeBlanc, Regan, Dayie, T. Kwaku, Onuchic, José N., Sanbonmatsu, Karissa Y.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352136/
https://ncbi.nlm.nih.gov/pubmed/28248966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005406
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