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4-Hydroxyestradiol induces mammary epithelial cell transformation through Nrf2-mediated heme oxygenase-1 overexpression
Estrogen (17β-estradiol, E(2)) undergoes oxidative metabolism by CYP1B1 to form 4-hydroxyestradiol (4-OHE(2)), a putative carcinogenic metabolite of estrogen. Our previous study showed that 4-OHE(2)-induced production of reactive oxygen species contributed to neoplastic transformation of human breas...
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| Publicado no: | Oncotarget |
|---|---|
| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5352084/ https://ncbi.nlm.nih.gov/pubmed/27438141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10516 |
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