Soluble insulin analogs combining rapid- and long-acting hypoglycemic properties – From an efficient E. coli expression system to a pharmaceutical formulation

The discovery of insulin led to a revolution in diabetes management. Since then, many improvements have been introduced to insulin preparations. The availability of molecular genetic techniques has enabled the creation of insulin analogs by changing the structure of the native protein in order to im...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mikiewicz, Diana, Bierczyńska-Krzysik, Anna, Sobolewska, Agnieszka, Stadnik, Dorota, Bogiel, Monika, Pawłowska, Monika, Wójtowicz-Krawiec, Anna, Baran, Piotr A., Łukasiewicz, Natalia, Romanik-Chruścielewska, Agnieszka, Sokołowska, Iwona, Stadnik, Jacek, Borowicz, Piotr, Płucienniczak, Grażyna, Płucienniczak, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351984/
https://ncbi.nlm.nih.gov/pubmed/28296883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172600
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