Adenosine 5′-monophosphate blocks acetaminophen toxicity by increasing ubiquitination-mediated ASK1 degradation

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver failure in the world. Hepatic c-jun NH2-terminal protein kinase (JNK) activation is thought to be a consequence of oxidative stress produced during APAP metabolism. Activation of JNK signals causes hepatocellular damage w...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yang, Xiao, Zhan, Yibei, Sun, Qi, Xu, Xi, Kong, Yi, Zhang, Jianfa
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351630/
https://ncbi.nlm.nih.gov/pubmed/28031524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14059
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