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Sodium Channel Inhibitors Reduce DMPK mRNA and Protein
Myotonic dystrophy type 1 (DM1) is caused by an expanded trinucleotide (CTG)n tract in the 3′ untranslated region (UTR) of the dystrophia myotonica protein kinase (DMPK) gene. This results in the aggregation of an expanded mRNA forming toxic intranuclear foci which sequester splicing factors. We bel...
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| Publicado no: | Clin Transl Sci |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5351028/ https://ncbi.nlm.nih.gov/pubmed/26011798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12275 |
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