Sodium Channel Inhibitors Reduce DMPK mRNA and Protein

Myotonic dystrophy type 1 (DM1) is caused by an expanded trinucleotide (CTG)n tract in the 3′ untranslated region (UTR) of the dystrophia myotonica protein kinase (DMPK) gene. This results in the aggregation of an expanded mRNA forming toxic intranuclear foci which sequester splicing factors. We bel...

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Bibliografiske detaljer
Udgivet i:Clin Transl Sci
Main Authors: Witherspoon, Luke, O'Reilly, Sean, Hadwen, Jeremiah, Tasnim, Nafisa, MacKenzie, Alex, Farooq, Faraz
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Original Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351028/
https://ncbi.nlm.nih.gov/pubmed/26011798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12275
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