High‐fat diet induces protein kinase A and G‐protein receptor kinase phosphorylation of β(2)‐adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts

KEY POINTS: Patients with diabetes show a blunted cardiac inotropic response to β‐adrenergic stimulation despite normal cardiac contractile reserve. Acute insulin stimulation impairs β‐adrenergically induced contractile function in isolated cardiomyocytes and Langendorff‐perfused hearts. In this stu...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Fu, Qin, Hu, Yuting, Wang, Qingtong, Liu, Yongming, Li, Ning, Xu, Bing, Kim, Sungjin, Chiamvimonvat, Nipavan, Xiang, Yang K.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350441/
https://ncbi.nlm.nih.gov/pubmed/27983752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273314
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