NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease

Background and Aims. The nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) inflammasome has been implicated in the pathogenesis of chronic kidney disease (CKD); however, its exact role in glomerular injury and tubulointerstitial fibrosis is still undefined. The present study...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Guo, Honglei, Bi, Xiao, Zhou, Ping, Zhu, Shijian, Ding, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350413/
https://ncbi.nlm.nih.gov/pubmed/28348462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/8316560
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