Pentoxifylline Regulates Plasminogen Activator Inhibitor-1 Expression and Protein Kinase A Phosphorylation in Radiation-Induced Lung Fibrosis

Purpose. Radiation-induced lung fibrosis (RILF) is a serious late complication of radiotherapy. In vitro studies have demonstrated that pentoxifylline (PTX) has suppressing effects in extracellular matrix production in fibroblasts, while the antifibrotic action of PTX alone using clinical dose is ye...

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Publicat a:Biomed Res Int
Autors principals: Lee, Jong-Geol, Shim, Sehwan, Kim, Min-Jung, Myung, Jae Kyung, Jang, Won-Suk, Bae, Chang-Hwan, Lee, Sun-Joo, Kim, Kyeong Min, Jin, Young-Woo, Lee, Seung-Sook, Park, Sunhoo
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350299/
https://ncbi.nlm.nih.gov/pubmed/28337441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/1279280
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