Pentoxifylline Regulates Plasminogen Activator Inhibitor-1 Expression and Protein Kinase A Phosphorylation in Radiation-Induced Lung Fibrosis

Purpose. Radiation-induced lung fibrosis (RILF) is a serious late complication of radiotherapy. In vitro studies have demonstrated that pentoxifylline (PTX) has suppressing effects in extracellular matrix production in fibroblasts, while the antifibrotic action of PTX alone using clinical dose is ye...

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Bibliographische Detailangaben
Veröffentlicht in:Biomed Res Int
Hauptverfasser: Lee, Jong-Geol, Shim, Sehwan, Kim, Min-Jung, Myung, Jae Kyung, Jang, Won-Suk, Bae, Chang-Hwan, Lee, Sun-Joo, Kim, Kyeong Min, Jin, Young-Woo, Lee, Seung-Sook, Park, Sunhoo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350299/
https://ncbi.nlm.nih.gov/pubmed/28337441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/1279280
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