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Pentoxifylline Regulates Plasminogen Activator Inhibitor-1 Expression and Protein Kinase A Phosphorylation in Radiation-Induced Lung Fibrosis

Purpose. Radiation-induced lung fibrosis (RILF) is a serious late complication of radiotherapy. In vitro studies have demonstrated that pentoxifylline (PTX) has suppressing effects in extracellular matrix production in fibroblasts, while the antifibrotic action of PTX alone using clinical dose is ye...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Lee, Jong-Geol, Shim, Sehwan, Kim, Min-Jung, Myung, Jae Kyung, Jang, Won-Suk, Bae, Chang-Hwan, Lee, Sun-Joo, Kim, Kyeong Min, Jin, Young-Woo, Lee, Seung-Sook, Park, Sunhoo
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350299/
https://ncbi.nlm.nih.gov/pubmed/28337441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/1279280
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