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Cthrc1 lowers pulmonary collagen associated with bleomycin‐induced fibrosis and protects lung function

Idiopathic pulmonary fibrosis (IPF) involves collagen deposition that results in a progressive decline in lung function. This process involves activation of Smad2/3 by transforming growth factor (TGF)‐β and Wnt signaling pathways. Collagen Triple Helix Repeat‐Containing‐1 (Cthrc1) protein inhibits S...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Binks, Andrew P., Beyer, Megyn, Miller, Ryan, LeClair, Renee J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350163/
https://ncbi.nlm.nih.gov/pubmed/28292882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13115
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