An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients

Alzheimer's disease (AD) is the most common cause of dementia and is likely caused by defective amyloid precursor protein (APP) trafficking and processing in neurons leading to amyloid plaques containing the amyloid-β (Aβ) APP peptide byproducts. Understanding how APP is targeted to selected de...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Front Mol Neurosci
Main Authors: Poulsen, Ebbe T., Iannuzzi, Filomena, Rasmussen, Helle F., Maier, Thorsten J., Enghild, Jan J., Jørgensen, Arne L., Matrone, Carmela
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2017
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350151/
https://ncbi.nlm.nih.gov/pubmed/28360834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00059
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki