An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients

Alzheimer's disease (AD) is the most common cause of dementia and is likely caused by defective amyloid precursor protein (APP) trafficking and processing in neurons leading to amyloid plaques containing the amyloid-β (Aβ) APP peptide byproducts. Understanding how APP is targeted to selected de...

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Detaylı Bibliyografya
Yayımlandı:Front Mol Neurosci
Asıl Yazarlar: Poulsen, Ebbe T., Iannuzzi, Filomena, Rasmussen, Helle F., Maier, Thorsten J., Enghild, Jan J., Jørgensen, Arne L., Matrone, Carmela
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2017
Konular:
Neuroscience
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350151/
https://ncbi.nlm.nih.gov/pubmed/28360834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00059
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