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Efficient Binding of the NOS1AP C-Terminus to the nNOS PDZ Pocket Requires the Concerted Action of the PDZ Ligand Motif, the Internal ExF Site and Structural Integrity of an Independent Element

Neuronal nitric oxide synthase is widely regarded as an important contributor to a number of disorders of excitable tissues. Recently the adaptor protein NOS1AP has emerged as a contributor to several nNOS-linked conditions. As a consequence, the unexpectedly complex mechanisms of interaction betwee...

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Détails bibliographiques
Publié dans:Front Mol Neurosci
Auteurs principaux: Li, Li-Li, Cisek, Katryna, Courtney, Michael J.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350102/
https://ncbi.nlm.nih.gov/pubmed/28360833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00058
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