Decreased Gaq expression in T cells correlates with enhanced cytokine production and disease activity in systemic lupus erythematosus

Aberrant T cell immune responses appear central to the development of systemic lupus erythematosus (SLE). We previously reported that Gαq, the alpha subunit of Gq, regulates T and B cell immune responses, promoting autoimmunity. To address whether Gαq contributes to the pathogenesis of SLE, Gαq mRNA...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: He, Yan, Huang, Yan, Tu, Lei, Luo, Jiao, Yu, Bing, Qian, Hongyan, Duan, Lihua, Shi, Guixiu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper: Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349870/
https://ncbi.nlm.nih.gov/pubmed/27965465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13903
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