Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B(4) production

Propofol is an intravenous anesthetic that produces its anesthetic effect, largely via the GABA(A) receptor in the CNS, and also reduces the N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced neutrophil respiratory burst. Because fMLP-stimulated neutrophils produce leukotriene (LT)B(4), we exami...

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書目詳細資料
發表在:FASEB J
Main Authors: Okuno, Toshiaki, Koutsogiannaki, Sophia, Ohba, Mai, Chamberlain, Matthew, Bu, Weiming, Lin, Fu-Yan, Eckenhoff, Roderic G., Yokomizo, Takehiko, Yuki, Koichi
格式: Artigo
語言:Inglês
出版: Federation of American Societies for Experimental Biology 2017
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349797/
https://ncbi.nlm.nih.gov/pubmed/28069825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601095R
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