Overexpression of decorin promoted angiogenesis in diabetic cardiomyopathy via IGF1R-AKT-VEGF signaling

Microcirculatory dysfunction is believed to play an important role in diabetic cardiomyopathy. The small leucine-rich proteoglycan decorin is generally considered a pro-angiogenic factor. Here, we investigate whether overexpression of decorin ameliorates diabetic cardiomyopathy and its effects on an...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lai, Jinsheng, Chen, Fuqiong, Chen, Jing, Ruan, Guoran, He, Mengying, Chen, Chen, Tang, Jiarong, Wang, Dao Wen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349602/
https://ncbi.nlm.nih.gov/pubmed/28290552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44473
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