Everolimus treatment for neuroendocrine tumors: latest results and clinical potential

Neuroendocrine tumors (NETs) are a heterogeneous class of diseases characterized by challenging management. Preclinical evidence shows that the PI3K/AKT/mTOR signaling pathway plays a central role in the pathogenesis and progression of NETs. Everolimus is a direct inhibitor of this pathway, and ther...

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Veröffentlicht in:Ther Adv Med Oncol
Hauptverfasser: Pusceddu, Sara, Verzoni, Elena, Prinzi, Natialie, Mennitto, Alessia, Femia, Daniela, Grassi, Paolo, Concas, Laura, Vernieri, Claudio, Lo Russo, Giuseppe, Procopio, Giuseppe
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349426/
https://ncbi.nlm.nih.gov/pubmed/28344663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758834016683905
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