Microglia-derived IL-1β contributes to axon development disorders and synaptic deficit through p38-MAPK signal pathway in septic neonatal rats

BACKGROUND: Axon development plays a pivotal role in the formation of synapse, nodes of Ranvier, and myelin sheath. Interleukin-1β (IL-1β) produced by microglia may cause myelination disturbances through suppression of oligodendrocyte progenitor cell maturation in the septic neonatal rats. Here, we...

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Udgivet i:J Neuroinflammation
Main Authors: Han, Qianpeng, Lin, Qiongyu, Huang, Peixian, Chen, Mengmeng, Hu, Xin, Fu, Hui, He, Shaoru, Shen, Fengcai, Zeng, Hongke, Deng, Yiyu
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348817/
https://ncbi.nlm.nih.gov/pubmed/28288671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0805-x
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